Biography

Doctoral dissertation defended 04/13/2013. entitled: “The importance of determining microsatellite instability as a genetic marker in colorectal cancer”, Faculty of Medicine, University of Belgrade.  The narrower scientific field is molecular medicine.

Commission members: Prof. Dr. Svetozar Damjanović, Prof. Dr. Zorica Stojšić, Prof. Dr. Njegica Jojić Mentor: Prof. Dr. Zoran Krivokapić,

Commentator: Prof. Dr. Svetislav Tatić

Specialization in Internal Medicine 2010-2014, passed the specialist exam in the field of Internal Medicine in 2014 with excellent results (University of Belgrade, Faculty of Medicine).

He defended his specialization thesis entitled: “Optimization of biological therapy in patients with inflammatory bowel diseases“, Faculty of Medicine, University of Belgrade, in January 2020. The narrower scientific field of gastroenterology.

Commission members: Prof. Dr. Dragan Popović and Prof. Dr. Srđan Đuranović

Mentor: Prof. Dr. Petar Svorcan

1. Jonaitis L,  Marković S , Farkas K, Gheorghe L, Krznarić Ž, Salupere R, et al. . Intravenous versus subcutaneous delivery of biotherapeutics in  IBD : an expert’s and patient’s perspective. BMC Proc. 2021 Dec 9;15(Suppl 17):25. (IF 1.57, M22)
2. Markovic S, Jankovic M, Kalaba A, Zogovic B, Sreckovic S. Infliximab Rescue in Acute Severe Ulcerative Colitis Complicated by Clostridium Difficile Infection: A Case Series. 2021 Oct 25;13(10):e19019. (IF 1.15, M23)
3. Markovic S, Ivanovski TK, Zogovic B, Kalaba A, Zaric D, Svorcan P. The Effect of COVID-19 Resurgence on Morbidity and Mortality in Patients With IBD on Biologic Therapy. Inflammable Bowel Dis. Inflamm Bowel Dis. 2021 Mar 9:izab048. doi: 10.1093/ibd/izab048 (IF 5.325, M21)
4. Markovic S, Sreckovic S, Zogovic B, Svorcan P. Postoperative Crohn’s Disease and Relapse Risk Factors: A Single Center Experience. Acta Scientific Gastrointestinal Disorders. 2021; 4 (3): 19-26. (IF 0.835, M23)
5. Markovic S, Panic N, Zogovic B, Kalaba A, Jankovic M, Knezevic Ivanovski T, Tarabar D, Svorcan P. Short Term Outcome of Saccharomyces boulardii impact the Quality of Life in Patients with Inflammatory Bowel Diseases: A Multicenter, Double Blind, Placebo -Controlled trial. Acta Scientific Gastrointestinal Disorders. 2021; 4 (3): 27-34 (IF 0.835, M23)
6. Markovic S, Ivanovski TK, Zogovic B, Cvetkovic M, Svorcan P. Biological Therapy for Inflammatory Bowel Disease During the COVID-19 Pandemic: Experiences From a Tertiary IBD Service. Inflamm Bowel Dis. 2020 Nov 19;26(12):e152.. (IF 5.325 M21)
7. Despotović SZ, Milićević NM, Milošević DP, Despotović N, Erceg P, Svorcan P, Schumacher U, Ullrich S, Mihajlović G, Kalem D, Marković S, Lalić IM, Krmpot AJ, Rabasović MD, Pantelić DV, Jovanić SZ, Rösch T , Milićević Ž. Remodeling of the extracellular matrix of the lamina propria in the uninvolved human rectal mucosa 10 and 20 cm away from the malignant tumor. Tumor Biol. 2017 Jul;39(7):1010428317711654. (IF 3.048, M21)
8. Protic M, Markovic S, Tarabar D. Case Report: Acute Flair of Ulcerative Colitis during Pregnancy Is Still a Major Problem. Dig Dis. 2017;35(1-2):134-138. doi: 10.1159/000449094. (IF 2.404, M21)
9. Markovic S, Dimitrijevic I, Zogovic B, Markovic V, Barisic G, Krivokapic Z. Current trends in clinical genetics of colorectal cancer. J BUON. 2016 Sept-Oct;21(5):1042-1049. (IF 2.533, M22)
10. Markovic S, Antic J, Dimitrijevic I, Zogovic B, Bojic D, Svorcan P, Markovic V, Krivokapic Z. Microsatellite instability and survival in patients with stage II/III colorectal carcinoma. Indian Journal of Medical Research (IJMR), 2016; 143 (7): 104-111. (IF 2.375, M23)
11. Markovic S, Antic J, Dimitrijevic I, Zogovic B, Bojic D, Svorcan P, Markovic V, Krivokapic Z. Microsatellite instability affecting the T17 repeats in intron 8 of HSP110, as well as five mononucleotide repeats in patients with colorectal carcinoma. Biomark Med. 2013;7(4):613-21. (IF 2.02 M22)
12. Krivokapić Z, Marković S, Antic J, Dimitrijević I, Bojić D, Svorcan P, Jojić N, Damjanović S. Clinical and pathological tools for identifying microsatellite instability in colorectal cancer. Croat Med J. 2012;53(4):328-35. (IF 1.351; M22)
13. Markovic S, Antic J, Dragicevic N, Hamelin R, Krivokapic Z. High-frequency microsatellite instability and BRAF mutation (V600E) in unselected Serbian patients with colorectal cancer. J Mol Histol. 2012;43(2):137-43. (IF 2.531; M22)
14. Bojic D, Markovic S. Terminal ileitis is not always Crohn’s disease. Annals of Gastroenterology.2011; 24: 271-275.
15. Markovic S, Jankovic M, Zaric D, Kalaba A, Vrinic D, Sreckovic S, Svorcan P. Use of Methotrexate in treatment of inflammatory bowel disease. Zvezdara Clin Proc 2018; 19 (1-2): 17-20.
16. Stefanovic K, Gligorijevic G, Jojic B, Vuksanovic M, Janosevic B, Markovic S. From hyponatremia to hypopituitarism. Zvezdara Clin Proc 2013; 14 (1-2):20-23.
17. Svorcan P, Markovic S, Bojic B, Djordjevic J, Bojic D, Protic M, Vrinic D, Kazic S, Jojic Nj. Clinical aspects of portal hypertension in patients with liver cirrhosis. Arch Gastroenterohepatol 2012; 29 (2) 44-50.
18. Bojic D, Markovic S, Bojic B, Maksimovic B, Sreckovic S, Kalem D, Svorcan P, Protic M, Jojic Nj. NSAID colopathy: our cases and literature review. Arch Gastroenterohepatol 2012;29(2):12-17.
19. Bojic D, Maksimovic B, Markovic S, Bojic B, SVorcan P, Jojic Nj. Primary epiploic appendagitis as a very rare cause of abdominal pain – case report. Arch Gastroenterohepatol 2012;29(3):40-43.
20. Maksimovic B, Markovic S, Gligorijevic V, Svorcan P, Jojic N, Bojic D. Modern fecal markers of pancreatic and intestinal inflammation – our experience. Zvezdara Clin Proc 2012;13(1-2):12-15.
21. Svorcan P, Markovic S. Emergency conditions in hepatology. Zvezdara Clinic Proceeding 2011; 11(1-2):61-63.Markovic M, Markovic S. Homocysteine ​​from physiology to clinical practice in neurology. Apollineum medicum et aesculapium. 2011; 9:1.
22. Svorcan P, Markovic S, Bojic D, Djordjevic J, Vrinic D, Kazic S, Dapcevic B. Clinical and pathophysiological characteristics of autoimmune pancreatitis. Internist 2010; 2(1):77-83.
23. Svorcan P, Markovic S, Djordjevic J, Bojic D, Vrinic D, Kazic S, Gligorijevic V, Jojic Nj. Bile salts and chronic liver diseases associated with cholestasis Zvezdara Clinic Proceeding. 2011; 12 (1-2):32-36.
24. Svorcan P, Markovic S, Djordjevic J, Vrinic D, Bojic D, Kazic S, Jojic Nj. Hepatocellular carcinoma – from epidemiology to therapy. Internist 2010; 2 (3):141-147.
25. Svorcan P, Markovic S, Bojic D, Protic M, Dapcevic B. Clinical monitoring and management of patients with liver cirrhosis. Internist 2009; 1(2):51-58.
26. Svorcan P, Markovic S, Djordjevic J, Bojic D, Protic M, Dapcevic B. Etiological and clinical aspects of acute and chronic portal thrombosis. Zvezdara Clin Proc 2009; 10 (1-2): 11-18.
27. Svorcan P, Markovic S, Dapčević B. Hyperbilirubinemia. Arch Gastroenterohepatol 2008; 27 (3-4): 77-88.
28. Knezevic, M Milic, A Kalaba, S Sreckovic, B Stopic, P Svorcan, S Markovic. Is mucosal healing a sufficient parameter for anti-TNF discontinuation? Journal of Crohn’s and Colitis, Volume 14, Issue Supplement_1, January 2020, Pages S433–S434, https://doi.org/10.1093/ecco-jcc/jjz203.626
29. Mitrovic M, Markovic S, Vrinic Kalem D, Jankovic A, Svorcan P. Helicobacter Pylori infection and Nutritional Status in End Stage Renal Disease Patients. UEGW.11-13. Oct 2020.
30. A Kalaba, M Markovic, M Jankovic, D Zaric, S Markovic, P Svorcan. Quality of life of patients with inflammatory bowel diseases in remission on different forms of treatment. Journal of Crohn’s and Colitis, Volume 13, Issue Supplement_1, March 2019, Pages S289–S290, https://doi.org/10.1093/ecco-jcc/jjy222.494
31. Markovic S., Kalaba A, Jankovic M, Vrinic D, Zaric D, Svorcan P. Pneumoperitoneum in ulcerative colitis is not always an indication for urgent colectomy. European Conference of young Gastroenterologists. Dec. 2018. Zagreb. Croatia.
32. Markovic S., Jankovic M, Kalaba A, Zaric D. Fulminant ulcerative colitis, Clostridium infection and anti-TNF rescue therapy. European Conference of young Gastroenterologists. Dec. 2018. Zagreb. Croatia.
33. Knezevic Ivanovski, S. Knezevic Usaj, V. Gligorijevic, Markovic S, P. Svorcan, M. Nedeljkovic Protic Fecal calprotectin as suitable biomarker in evaluation of histological disease Activity, poster presentation, available online P236, ECCO 12, Barcelona/Spain, 16 – 18.02.2017,
34. Markovic S, Krstic M, Antic J, Dimitrijevic I, Markovic V, Svorcan P, Nedeljkovic-Protic M, Krivokapic Z, Microsatellite instability affecting the T17 repeats in intron 8 of HSP110 in patients with colorectal carcinoma. Fit for the Future in Gastroenterology Meeting. EAGEN & EHMSG POSTGRADUATE COURSE 2017, Berlin.
35. Markovic S, Krstic M, Antic J, Dimitrijevic I, Svorcan P, Krivokapic Z, Genetic markers of hereditary colon cancer – important contribution to Lynch syndrome screening in Serbia Fit for the Future in Gastroenterology Meeting. EAGEN & EHMSG POSTGRADUATE COURSE 2016, Berlin
36. Markovic S., Antic J., Dimitrijevic I. Markovic M. Krivokapic Z. Microsatellite instability and hmlh1 promoter gene methylation analysis – important contribution to lynch syndrome screening in Serbia. 10th biannual. International symposium of coloproctology October 13 – 15th, 2016. Belgrade, Serbia
37. Markovic S, Krstic M, Antic J, Dimitrijevic I, Svorcan P, Krivokapic Z, hMLH1 promoter gene methylation, BRAF mutation and microsatellite instability in colorectal cancer – Serbian cases. Fit for the Future in Gastroenterology Meeting. EAGEN & EHMSG POSTGRADUATE COURSE 2015, Berlin
38. Markovic S. 3 key clinical papers in ’17 on esophagus. Fit for the Future in Gastroenterology Meeting. EAGEN & EHMSG POSTGRADUATE COURSE 2017, Berlin.
39. Gligorijevic V, Bojic D, Markovic S, Maksimovic B, Gligorijevic G, Jojic N. The prevalence of iron deficiency and anemia in an IBD referral center in Serbia Journal of Crohn’s and Colitis.Feb 2014,8(Supplement 1)S116.
40. Markovic S, Antic J, Dimitrijevic I, Markovic V, Krivokapic Z. Correlation of hMLH1 promoter gene methylation and BRAF mutation in colorectal cancer with microsatellite instability 8th biannual symposium of coloproctology. White City. October 2014 (oral presentation)
41. Antic J, Markovic S, Krivokapic Z, Damjanovic S. MIcorsatellite instability, T 17 repeats region in intron 8 of HSP110 and BRAF in patients with colorectal carcinoma, ISCO2014 Cancer Genome: From Structure to Function, 11-14 May 2014, Malaga, Spain.
42. Markovic S, Antic J, Dimitrijevic I, Markovic V, Bojic D, Svorcan P, Jojic Nj, Krivokapic Z. Microsatellite instability and 5-FluoroUracil based chemotherapy in stage II and III colorectal cancer. 8th International Congress of the European Federation for Colorectal Cancer (EFR). Acta chirurgica austriaca; 45: (1) Supplement. April 2013
43. Markovic S: How does genetic testing influence management and outcome of colorectal cancer. 10th Congress of the European – African Hepato Pancreato Biliary Association (10th E–AHPBA Congress), May 2013. Belgrade (invited lecture).
44. Markovic S: Genetics of colorectal cancer. XIII National Conference of Coloproctology with International Participation. 27-28 September. 2013. Varna. Bulgaria (invited lecture).
45. Knezevic Ivanovski T, Knezevic Usaj S, Gligorijevic V, Markovic S, Svorcan P, Protic M Fecal calprotectin as suitable biomarker in assessment of histological and endoscopic disease activity, Falk symposia, 30.03.-01.04. Madrid/Spain, poster presentation
46. Marković S, Svorcan P, Gligorijević V, Knezevic-Ivanovski T, Srećković S, Nedeljković-Protic M. Risk factors for recurrence of postoperative Crohn’s Disease – single Center experience
47. Gligorijevic V, Knezevic Ivanovski T, Markovic S, Svorcan P, Protic M, Iron deficiency anemia in serbian ibd referral center, Falk symposia, 30.03.-01.04. Madrid/Spain, poster presentation
48. Markovic S, Antic J, Dimitrijevic I, Markovic V, Bojic D, Svorcan P, Krivokapic Z. High-frequency microsatellite instability and BRAF mutation (V600E) as prognostic indicators in colorectal cancer. 8th biannual symposium of coloproctology. White City. October 2012 (oral presentation)
49. Bojic B, Markovic S, Sreckovic S, Kalem D, Bojic D, Svorcan P, Protic M, Jojic Nj. Efficacy of Diosmin and band ligation in the treatment of haemorrhoidal disease. 8th biannual symposium of coloproctology. White City. October 2012
50. Markovic S, Antic J, Dimitrijevic I, Markovic V, Bojic D, Svorcan P, Krivokapic Z. Validity of revised Bethesda guidelines for identification of microsatellite instability in unselected colorectal cancers in Serbian patients. 8th biannual symposium of coloproctology. White City. October 2012. Third prize.
51. Markovic S, Antic J, Dimitrijevic I, Bojic D, Svorcan P, Jojic NJ, Krivokapic Z: Lymphocytic infiltrate as predictor of microsatellite instability in colorectal cancer? First report from Serbia. 7th International EFR Congress Surgical Congress: Multidisciplinary Treatment of Colorectal Cancer. Vienna, Austria, April 28-30, 2011. Eur Surg 2011: 43 (suppl 240):11. (Best abstract – Ingeborg Hörhager Prize).
52. Markovic S, Antic J, Dimitrijevic I, Markovic V, Bojic D, Svorcan P, Jojic NJ, Damjanovic S, Krivokapic Z: Clinico-pathological features and microsatellite instability in colorectal cancer in Serbian patients. II Congress of Gastroenterologists of Serbia with international participation. Belgrade 30.09.-02.10. 2011. Arch of gastroenterol 2011; 1-2: 65.
53. Markovic S, Dimitrijevic I, Svorcan P, Bojic D, Krivokapic Z: Histological Grade, Lymphocytic Infiltration and Mucin Production as Prognostic Indicators of Colorectal Carcinoma. 4th Congress of the Gastroenterology Association of Bosnia and Herzegovina. Sarajevo 25-28. May 2011.
54. Gligorijevic V, Bojic D, Protic-Nedeljkovic M, Svorcan P, Maksimovic B, Markovic S, Jojic NJ: Epidemiological study of inflammatory bowel disease in a single tertiary center-First report from Serbia. J Crohn’s Colitis 2011; 5(1); S153 (P339).
55. Bojic D, Bojic B, Jojic Nj, Svorcan P, Protic M, Markovic S, Maksimovic B, Milosevic D, Ben-Horin S. Tu1419 Ingestion of Inert Colonic Markers as a Novel Method for Predicting the Quality of Preparation for Colonoscopy. Gastrointestinal Endoscopy; 73, (4), AB402 – AB403.
56. Knežević Ivanovski T, Marković S, Kalaba A, Srećković S, Vrinić Kalem D, Zarić D, Odanović O, Svorcan P. Short-term results of treatment of inflammatory bowel diseases with Vedolizumab compared to previous treatment with antiTNF therapy. Second Congress of Gastroenterologists of Serbia, November 7-9, 2019, Book of abstracts
57. Marković S, Jankovic M, Kalaba A, Zarić D, Knežević Ivanovski T, Srećković S, Vrinić Kalem D, Svorcan P. Effect of Infliximab and Adalimumab drug levels on mucosal healing in patients with Crohn’s disease. Second Congress of Gastroenterologists of Serbia, November 7-9, 2019, Book of abstracts
58. Marković S, Panić N, Kalaba A, Janković M, Knežević Ivanovski T, Tarabar D, Svorcan P. Multicenter, placebo-controlled study of the quality of life of patients in remission of Crohn’s disease and ulcerative colitis with irritable bowel syndrome treated with conventional therapy with Bulardi® 500. Second Congress of Gastroenterologists of Serbia, November 7-9, 2019, Book of abstracts
59. Kalaba A, Markovic M, Jankovic M, Zaric D, Markovic S, Svorcan P. Assessment of quality of life with inflammatory bowel diseases on biological therapy in relation to other forms of treatment. Second Congress of Gastroenterologists of Serbia, November 7-9, 2019, Book of abstracts
60. Kalaba A, Markovic S, Jankovic M, Zaric D, Vrinic D, Sreckovic S, Svorcan P. Severe relapse of ulcerative colitis in patients with dementia: referral IBD unit experience. Second Congress of Gastroenterologists of Serbia, November 7-9, 2019, Book of abstracts
61. Knežević Ivanovski T, Marković S, Kalaba A, Srećković S, Vrinić Kalem D, Zarić D, Odanović O, Svorcan P. Results of the study of the efficacy and safety of vedlizumab in the treatment of inflammatory bowel diseases – experience of a reference center. Second Congress of Gastroenterologists of Serbia, November 7-9, 2019, Book of abstracts
62. Markovic S. Refractory celiac disease and malignancies, invited lecture, Celiac Symposium, Belgrade 2017.
63. Marković S. Antiplatelet and anticoagulant therapy in the elderly from the point of view of gastroenterohepatologists XVII Congress of the Association of Internists of Serbia, 2017.
64. Markovic S, Dimitrijevic I, Svorcan P, Bojic D, Markovic V, Krivokapic Z. Significance of preoperative value of serum carcinoembryonic antigen for recurrence in patients with colorectal cancer in stage II and III. XII Congress of the Association of Internists of Serbia. Collection of abstracts. Vrnjacka Spa. June 7-10, 2012; 23.
65. Markovic S, Dimitrijevic I, Bojic D, Svorcan P, Markovic V, Krivokapic Z: Specificity and sensitivity of tumor markers, CEA and Ca 19-9, for metastatic colorectal cancer. XI Congress of the Association of Internists of Serbia. Vrnjacka Spa 8-12.06.2011. Book of summaries, page 43 (P 69).
66. Markovic S, Krivokapic Z, Dimitrijevic I, Svorcan P, Bojic D. Clinical significance of lymphocytic infiltration in colorectal cancer. X Congress of the Association of Internists of Serbia. Belgrade 9-12.06.2010. Book of summaries p. 58 (P 103).
67. Bojic D, Bojic B, Protic M, Svorcan P, Necic D, Markovic S, Jojic Nj. Fecal calprotectin in the assessment of Crohn’s disease activity: correlation with the Harvey-Bradshow index, laboratory, endoscopic and histological findings. X Congress of the Association of Internists of Serbia. Belgrade 9-12.06.2010. Oral presentation. Book of summaries, page 21 (O 036).
68. Markovic S: How to monitor a patient diagnosed with inflammatory bowel disease?, 4th Congress of Gastroenterologists 2019, Belgrade
69. MarkovicS: How to recognize and treat irritable bowel syndrome in patients with inflammatory bowel disease? SIBDA, 2018. Belgrade
70. Markovic S: The role of Methotrexate in inflammatory bowel diseases. SIBDA, 2019. Belgrade
71. Markovic S. Refractory celiac disease and malignancies, invited lecture, Celiac Symposium, Belgrade 2017.
72. Markovic S: Genetics of colorectal cancer. XIII National Conference of Coloproctology with International Participation. 27-28 September. 2013. Varna. Bulgaria.

Markovic S: How does genetic testing influence management and outcome of colorectal cancer. 10th Congress of the European – African Hepato Pancreato Biliary Association (10th E–AHPBA Congress), May 2013. Belgrade.

Chapters in a monograph of prominent national importance

1. Markovic S. Krivokapic Z. Colon cancer: heredity and family. Chapter 3 – Colon cancer. And edition. SANU. Institute for textbooks, Belgrade. in 2018
2. Markovic S, Krivokapic Z. Chapter VII Hereditary carcinomas of the colon and rectum. Krivokapic Z. Cancer of the rectum: Chapter 7. Hereditary cancers of the colon and rectum. And edition. Institute for textbooks. Belgrade 2012.

Chapter in the textbook

1. Svorcan P, Markovic S. Emergency conditions in gastroenterohepatology, Emergency medicine – for dental students. Faculty of Dentistry, Pancevo, 2015. 225-241.
2. Responsible editor and author of the IBD monograph in 12 lessons
3. Marković S , Svorcan P. Inflammatory bowel diseases in 12 lessons. Marković S. First edition. Clinical Hospital Center “Zvezdara”. Belgrade in 2022.

As the secretary of the gastroenterology section, he participated in the organization of meetings of the gastroenterology section since 2019. He actively participates in the activities of the Serbian Association for Inflammatory Bowel Diseases and the organization of expert meetings of the Association.

Reviewer in several international journals, one of which is Journal of Molecular Histology, IF 2.531.

He won the prize (Ingeborg Horhager Prize) for the best abstract and presentation at the European Congress dedicated to colorectal cancer in April 2011 in Vienna and the third prize at the International Coloproctology Congress in Belgrade in December 2012.

Participation in projects of the Ministry of Science of the Republic of Serbia

2008 – 2014

2008-2010: Name of the project “Factors influencing the occurrence of local recurrence, quality of life and functional results in patients operated on for rectal cancer”. No. ON145079, project leader – prof. Dr. Zoran Krivokapić.

2011-2014: The name of the project “The role of preoperative determination of disease stage, prognostic and therapeutic markers, objectification of functional results in the decision on the strategy of rectal cancer treatment, with the aim of improving oncological

As the secretary of the gastroenterology section, he participated in the organization of meetings of the gastroenterology section since 2019.

He actively participates in the activities of the Serbian Association for Inflammatory Bowel Diseases and the organization of expert meetings of the Association. Reviewer in several international journals, one of which is Journal of Molecular Histology, IF 2.531.

He won the prize (Ingeborg Horhager Prize) for the best abstract and presentation at the European Congress dedicated to colorectal cancer in April 2011 in Vienna and the third prize at the International Coloproctology Congress in Belgrade in December 2012.

2008-2010: Name of the project “Factors influencing the occurrence of local recurrence, quality of life and functional results in patients operated on for rectal cancer“. No. ON145079, project leader – prof. Dr. Zoran Krivokapić.

2011-2014: The name of the project “The role of preoperative determination of disease stage, prognostic and therapeutic markers, objectification of functional results in the decision on the strategy of rectal cancer treatment, and in order to improve oncological”